Description

Regeneron Pharmaceuticals, Analytical and Biological Mass Spectrometry Group (ABMS), located in Tarrytown, NY is seeking a motivated Associate Scientist to join our fast-paced and interdisciplinary team working on analytical and bioanalytical
development on novel siRNA/oligonucleotide-based modalities in a diverse genetic medicine pipeline. In this role, you will develop and optimize liquid chromatography coupled to mass spectrometry (LC-MS) related methods for the enrichment, detection,  quantification, and structural characterization of siRNAs, oligonucleotides, novel siRNA conjugates and monoclonal antibodies (mAbs). You will perform analytical testing and sample preparation of siRNA/oligonucleotides with a focus on chromatographic fractionation, LC, LC-MS, solid phase extraction (SPE), hybridization-capture, and other mass spectrometry related methods. You will independently conduct sample preparation and LC-MS analyses in compliance with SOPs or drafted protocols, and document experimental procedures and results in electronic laboratory notebook (ELN).

A Typical Day in This Role Looks Like:
- Execute established protocols and clearly communicate analytical characterization of biotherapeutics, including siRNA and monoclonal and bispecific antibodies, and other modalities to support drug development.
- Execute characterization activities, with an emphasis on LC-MS technique to elucidate critical quality attributes such as structural isomers, size variants, and post-translational modifications.
- Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing to solve drug development challenges.
- Independently conduct sample preparation and LC-MS analyses in compliance with SOPs and document experimental procedures and results in electronic laboratory notebook (ELN).

Requirements

This Role May Be for You If:
- You thrive in a fast-paced, collaborative environment and consistently deliver results with efficiency and ownership.
- You quickly learn new technologies, solve complex problems, and demonstrate strong passion for science and innovation.
- You are self-motivated and proactive, with the ability to prioritize effectively and drive work forward with minimal supervision.

To be considered for this role, you must have a Bachelor’s or Master’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field. 

Familiarity with advanced mass spectrometers (Q Exactive Plus, Q Exactive UHMR, Q-TOF, etc.), liquid chromatography, multi-dimensional liquid chromatography, liquid-handling systems and data processing software (Skyline, Protein Metrics, etc.) is desired. 

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries’ specific benefits, please speak to your recruiter.

Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.